Kudos to ISER Members!
If you know of an ISER member who deserves special recognition, please notify the ISER Secretariat. We look forward to posting the professional achievements of our members!
- The L V Prasad Eye Institute recently published an article on the role of PRSS56 in the development and maintenance of ocular drainage tissues and IOP homeostasis that may provide some new insights into glaucoma pathogenesis. This work was based on a tripartite collaboration between the Dept. of Ophthalmology, UCSF.
The Jackson laboratory and the L V Prasad Eye Institute, Hyderabad, India.
- Salil Lachke, PhD was recently selected by the National Foundation for Eye Research (NFER) as the recipient of the 2020 NFER Cataract Research Award.
- The Lachke Lab just published a seminal paper showing that the RNA-binding protein RBM24 controls SOX2 in early eye development, defects in which causes microphthalmia and anophthalmia in mice. This paper was featured on the cover of Human Molecular Genetics.
The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development.
- The Lachke Lab also recently published the mouse embryonic lens proteome and applied a novel "in silico subtraction" strategy to prioritize cataract-linked proteins. This strategy can be extended to other ocular tissues.
MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
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